ABSTRACT Climate change and environmental pollution, which are strongly interconnected, threaten the health of current and future generations and require urgent and concrete action. On the back of this emergency, AMBO was born: an Alliance for an Environment Tailored to Children and Adolescents, which brings together 36 of the most prestigious scientific societies and associations [...]

ABSTRACT Familial Mediterranean fever is the oldest and most frequent autoinflammatory disease. It is also the first inflammatory condition for which a causative gene was identified. Colchicine represents the medication of choice for the management of FMF and is generally effective and well tolerated. However, a sizeable proportion of patients do not respond to this [...]

ABSTRACT Antimicrobial resistance (AMR) is an escalating threat to global public health, particularly affecting neonates and children. The incidence of infections caused by multi-resistant bacteria in these age groups is increasing, significantly impacting morbidity and mortality. A major factor contributing to AMR is the inappropriate use of antibiotics, often due to unnecessary prescriptions or incorrect [...]

ABSTRACT Anaphylaxis is a severe systemic allergic reaction that can have a rapid onset and may be fatal. Clinical manifestations often include prodromal symptoms followed by symptoms affecting the skin or mucous membranes, respiratory system, gastrointestinal system, cardiovascular system, and neurological system. Diagnosis is primarily based on clinical criteria. Treatment involves prompt recognition of the [...]

ABSTRACT According to the World Health Organization (WHO), obesity and overweight in childhood are among the main public health problems. Overweight is just the tip of the iceberg of a much more complex issue, leading to complications not only on a physical level but also on a psycho-social level. Diet and physical activity are the [...]

ABSTRACT Physical activity (PA) has an important role in developmental age as it significantly affects the global health and well-being of children and adolescents. PA should be understood as a spontaneous movement activity repeated over time, sports activity (SA) includes structured and regulated competitive situations. PA and FA are considered by the WHO to be [...]

ABSTRACT The incorporation of Artificial Intelligence (AI) and Large Language Models (LLMs) into healthcare systems represents a transformative process with potential impact and challenges for both medical residency education and clinical practice. LLMs, such as ChatGPT, are poised to revolutionize the lives of medical residents and health systems over the next decade. AI can assist [...]

ABSTRACT Pneumonia is an important and common cause of infection in pediatric patients. Most of these infections can be managed in an outpatient setting and don’t require specific diagnostic tests. Considering that viral infections are the most common cause of pneumonia, antibiotic therapies can be considered in light of the epidemiology and clinical presentation.   [...]

ABSTRACT There is a significant category of medications frequently used in daily practice by healthcare professionals known as “off-label”, meaning they are employed outside the approved indications for which they were originally marketed. This article aims to review the existing regulations, delineate the boundaries, and facilitate, where possible, the actions of physicians to enhance patient [...]